Novel strain creation

JAX® Services enables research with genetically-engineered mice from Ingenium, Ozgene and TIGM

If you can't find the genetically-engineered mouse strain you need in our extensive strain collection, you may be able to locate it or have it constructed at one of these institutions: Ingenium Pharmaceuticals, Ozgene, or the Texas Institute for Genomic Medicine (TIGM).

Each of these organizations has unique resources and capabilities which, in conjunction with JAX® Services, can produce and deliver genetically well-defined mutant mice quickly and cost-effectively.

JAX® Services can manage the entire process, allowing you to focus on your research. Our goal is to help you easily produce and obtain the strain or strains you need while saving you time, money, and resources.

Ingenium

Ingenium has a library of over 16,000 lines of cryopreserved mutant mouse sperm derived from a chemical mutagenesis program.  Each line contains approximately 20 point mutations in gene coding regions on a pure inbred background.  On average, 10 different alleles are available for each target gene in the library.  By using cryopreserved sperm and the rapid INGENOtyping® screening technology, mutant mouse lines can be delivered in less than four months.  The technology allows retrieval of a gene specific allelic series of mutants, representing hypo- and hypermorphic as well as null alleles.

Ozgene

Ozgene specializes in designing and constructing vectors, with which it produces knockout, knockin, conditional, humanized, transgenic, and lentiviral transgenic mice. Ozgene has been producing genetically-modified mice and rats for global markets for nearly 20 years. Its senior management team has published in leading scientific journals, including Nature, Science, EMBO, and PNAS. Ozgene scientists will work with you to develop a fully customized result.

Texas Institute for Genomic Medicine (TIGM)

TIGM maintains a gene trap library of mouse embryonic stem (ES) cell clones and provides both ES cells and breeder pairs of mice to academic and commercial institutions around the world. TIGM maintains sequence-tagged ES cell lines established on both a C57BL/6 genetic background (approximately 350,000 lines representing mutations in over 10,000 genes) and on a 129/SvEvBrd genetic background (over 270,000 lines representing mutations in over 9,000 genes). The National Institutes of Health has rights to a subset of these lines, allowing TIGM to distribute them to academic researchers on a subsidized basis. Together, these established resources provide unparalleled coverage of the mouse genome: over 620,000 cell lines representing mutations in over 13,000 unique genes. TIGM also has an extensive, user-friendly Internet-accessible database that allows users to search their libraries, inquire about a specific line, and place orders.

Have questions?

Contact us to discuss the advantages of each system and to understand how you can utilize our services with any novel strain to accelerate your research timeline.

The Jackson Laboratory is a not-for-profit research institute dedicated to facilitating the research of all scientists around the world by providing mice, mouse-based services and education. The above relationships are just three examples of how we serve the entire biomedical community by identifying new cutting edge technologies.

We encourage researchers, who use these technologies to create new strains of mice, to share them with other researchers. Information and resource sharing facilitated by The Jackson Laboratory through scientific presentations, publications and public databases helps the entire scientific community accelerate research and discovery. Our goal is to help in the development, characterization, and distribution of new mouse models of human disease that will lead to better understanding and treatment of human disease.