JAX® Phenotyping Services
The cost-effective, high-throughput, and noninvasive physiological test platforms in our phenotyping laboratory are specifically designed to characterize mouse models of human disease and use mice to test drug targets and drug efficacy.
Key benefits
- State-of-the-art phenotyping laboratory: broad selection of cost-effective, noninvasive, and high-throughput physiological tests for phenotyping and evaluating compounds in mice
- 80 years of experience in mouse biology, genetics, and physiology
- Standard and custom protocols executed without a hitch
Capabilities
| Measure(s) | Test platform(s) |
|---|---|
| Total body fat, lean mass, body fluids, total body water, and bone mineral density and content | EchoMRI, Piximus2 DEXA Scanner |
| Locomotor activity | San Diego Instruments SMART System |
| Muscle strength, neuromuscular integration | Columbus Instruments Grip Strength Meter |
| Hippocampal-dependent learning | Morris Water Maze |
| Motor coordination, fatigue resistance | Columbus Instruments Rotorod |
| Pain reflex | Columbus Instruments Hot Plate Analgesia Meter, Von Frey Mechanical Stimulus |
| Systolic blood pressure, pulse | CODA 6 Blood Pressure System |
| Heart rate, ECG | AnonyMOUSE ECG |
| Respiratory function | BUXCO Electronics Whole Body Plethysmograph |
| CO2 production, O2 uptake, food and water intake, circadian patterns | Columbus Instruments Comprehensive Cage Monitoring System |
| Real-time monitoring of cellular activity through bioluminescent reporters in live mice | Caliper Life Sciences IVIS® Lumina |
| All platforms are high-throughput and non-invasive. Mice are anethetized for DEXA scanning. | |
Supporting services
- Pathology— The Jackson Laboratory and UC Davis Comparative Pathology Lab (CPL)
- Blood Chemistry— The Jackson Laboratory and UC Davis CPL
- A network of supporting service providers offering biomarker analysis and specialty imaging modalities
Test requirements
- One year health history of client provided mice
- New models: a minimum of six mice per sex per genotype; more for compound screening or for in-depth studies (e.g., behavior)
- Recommended age ranges vary depending upon the test
