Compound evaluation servies: Obesity and type 2 diabetes
Comparison of common diabetes and obesity phenotypes among humans and commonly used JAX® Mice models
| Human |
NONcNZO10/LtJ (004456) |
KK.Cg-Ay/J (002468) |
BKS.Cg-Dock7m +/+ Leprdb/J(000642) | B6.V-Lepob/J (000632) |
DIO (000664, fed high fat diet) | |
|---|---|---|---|---|---|---|
| Genetics/Degree of Obesity | Polygenic/ Moderate |
Polygenic/ Moderate |
Monogenic/ Moderate |
Monogenic/ Severe |
Monogenic/ Severe |
Polygenic/ Moderate |
| Genetics/Degree of Diabetes (Hyperglycemia) | Polygenic/ Moderate1 |
Polygenic/ Severe1 |
Polygenic/ Severe1 |
Polygenic/ Severe2 |
Polygenic/ Severe1,3 |
Polygenic/ Moderate1 |
| Insulin Resistance | Moderate-Severe | Moderate | Moderate | Severe | Severe | Moderate |
| Islet Atrophy | Variable | Yes | No | Yes | No | No |
| Hypercorticism | No | No | ND* | Yes | Yes | No |
| 1 gradual onset 2 early, rapid onset 3 spontaneous remission of peripubertal hyperglycemia * not determined | ||||||
Supporting services
- Histopathology - The Jackson Laboratory and UC Davis Comparative Pathology Lab (CPL)
- Blood chemistry - The Jackson Laboratory and UC Davis CPL
- A network of supporting service providers offering biomarker analysis and specialty imaging modalities
Related links
- Print-Friendly Efficacy Testing Services for Diabetes & Obesity fact sheet (.pdf)
- Download a sample diabetes study design (.pdf)
- Download protocols and data from a wound healing pilot study (.pdf)
- Print-Friendly In Vivo Services brochure (.pdf)
Scientific advisor
Our Study Directors are supported by Jackson Laboratory scientist Ed Leiter, Ph.D.
Still have questions?
- Get started using our JAX® Services Request Form
- Ask JAX® Services a question via email.
- Call JAX® Services at 1-800-422-6423 (US, Canada & Puerto Rico) or 1-207-288-6294 (from any location).
- Contact your Regional Representative.
