PDX LiveTM tumors

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We have partnered with more than 20 cancer clinics to provide access to a wider range of patient-derived xenograft (PDX) cancer models at earlier passage numbers than any other PDX collection available today.

Executing patient-derived xenograft studies is time-consuming, with pre-study engraftment and growth of tumors representing a significant time investment. To streamline PDX cancer study execution, we are offering a collection of PDX LiveTM tumor engrafted NSG mice.

Our collection of readily available, off-the-shelf, tumor engrafted cohorts of PDX mice are developed and maintained by our experienced scientific staff and tumor-bearing mice are ready to quickly enroll on study.

Get your data up to 80% faster

Bringing tumors out of the freezer or passaging tumors between donor and on-study mice can delay PDX drug efficacy studies 6-12 weeks or more. Our inventoried PDX LiveTM tumors significantly shorten this time period by having tumor-engrafted live mice on the shelf and ready to enroll on study as soon as you are ready.

For most of our PDX tumors, gene expression data and genomic data (Affymetrix Human Gene 1.0 ST Exon Array), Genome-Wide Human SNP Array 6.0 from Affymetrix, including CNV data), standard of care data and pathology images are available through the Mouse Tumor Biology Database.

Breast tumor models

We are featuring off-the-shelf breast tumor models including several invasive ductal carcinomas with available gene expression, gene CNV and drug response data. The following models are currently growing in mice for quick availability.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00089 Breast Triple-negative PR-, ER-, HER2-. SOC available
TM00090 Breast Invasive ductal carcinoma SOC available; View data
TM00097 Breast Ductal carcinoma SOC available; TP53; KRAS
TM00103 Breast Ductal carcinoma GNAQ Y101. View Data
TM00107 Breast Carcinoma View data
TM00129 Breast Invasive ductal carcinoma PR-, ER-, HER2 (ERBB2)+
TM00999 Breast Invasive ductal carcinoma View data

 

Lung tumor models

Our extensive collection of early passage lung tumor models features various combinations of variants including ALK,KRAS, TP53 and EGFR.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00185 Lung Squamous cell carcinoma SOC available; View data
TM00192 Lung Adenocarcinoma AURKA F31I; KDR Q472H; Amplification of AURKA,CDK4/6 & EGFR
TM00193 Lung NSCLC: Adenocarcinoma EGFR exon 19 del
TM00200 Lung Small cell lung cancer View data
TM00204 Lung NSCLC: Adenocarcinoma EGFR exon 19 del; T790M
TM00206 Lung NSCLC: Adenocarcinoma ELM4 ALK
TM00208 Lung NSCLC: Squamous cell carcinoma AURKA F31; KDR Q472H; RET G691S; Amplification of CCNE1 & EGFR 
TM00219 Lung NSCLC: Adenocarcinoma CTNNB1, EGFR exon 19 del, T790M, KDR, TP53
TM00226 Lung NSCLC: Adenocarcinoma KRAS G13R
TM00233 Lung NSCLC View data
TM00355 Lung NSCLC: Metastatic adenocarcinoma SOC available; KRAS; ALK

 

Lymphomas and hematological tumor models

We are featuring a patient-derived xenograft model of AML positive for internal tandem duplication mutations of FMS-like tyrosine kinase-3 (FLT3-IDT).

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00346 Bone marrow Acute myeloid leukemia FLT3-ITD

 

Bladder tumor models

Our live bladder tumor models feature an early passage urothelial carcinoma with available gene expression, gene CNV and drug response data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00015 Bladder Urothelial carcinoma SOC available; TP53; PIK3CA
TM00020 Bladder Urothelial carcinoma View data

 

Brain tumor models

We are featuring a gliobastoma tumor model with available variant summary, gene expression, CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00058 Brain Gliobastoma View Data

 

Bone tumor models

Our featured live bone tumor model is an early passage osteosarcoma with variant summary, gene expression, CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00381 Bone Osteosarcoma KDR Q472H; FBXW7 R160* & R198*; Amplification of CTNNB1, MAP3K1 & PIK3R1
TM01165 Bone Rhabdomyosarcoma View data

 

Colon tumor models

Our featured live colon tumor PDX model is an early passage colon adenocarcinoma with gene expression, gene CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00134 Colon N/A View Data
TM00164 Colon Adenocarcinoma View Data

 

Ovarian tumor models

Our featured live ovarian tumor PDX models is an early passage carcinoma with gene expression, gene CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00330 Ovary N/A View Data
TM00334 Ovary N/A View Data
TM00391 Ovary Ovarian carcinoma View Data

 

Prostate tumor models

We are featuring a prostatic carcinoma tumor model with available variant summary, gene expression, CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00298 Prostate Prostatic carcinoma View Data

We also offer a variety of tumors available for engraftment for breast cancer, lung cancer, Bladder cancer, pancreatic cancer, acute myeloid leukemia, ovarian cancer and many others found in the mouse tumor database.