PDX LiveTM tumors

PDX Live buttons contactUs WhichTumorToEngraft SubscribeToPdxUdates

We have partnered with more than 20 cancer clinics to provide access to a wider range of patient-derived xenograft (PDX) cancer models at earlier passage numbers than any other PDX collection available today.

Executing patient-derived xenograft studies is time-consuming, with pre-study engraftment and growth of tumors representing a significant time investment. To streamline PDX cancer study execution, we are offering a collection of PDX LiveTM tumor engrafted NSG mice.

Our collection of readily available, off-the-shelf, tumor engrafted cohorts of PDX mice are developed and maintained by our experienced scientific staff and tumor-bearing mice are ready to quickly enroll on study.

Get your data up to 80% faster

Bringing tumors out of the freezer or passaging tumors between donor and on-study mice can delay PDX drug efficacy studies 6-12 weeks or more. Our inventoried PDX LiveTM tumors significantly shorten this time period by having tumor-engrafted live mice on the shelf and ready to enroll on study as soon as you are ready.

For most of our PDX tumors, gene expression data and genomic data (Affymetrix Human Gene 1.0 ST Exon Array), Genome-Wide Human SNP Array 6.0 from Affymetrix, including CNV data), standard of care data and pathology images are available through the Mouse Tumor Biology Database.

Breast tumor models

We are featuring off-the-shelf breast tumor models including several invasive ductal carcinomas with available gene expression, gene CNV and drug response data. The following models are currently growing in mice for quick availability.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00089 Breast Triple-negative PR-, ER-, HER2-; PDL1+; SOC available
TM00095 Breast Invasive ductal carcinoma PR-, ER-, HER2+; View data
TM00098 Breast Invasive ductal carcinoma KDR Q472H; MYC & JAK2 amplification. PDL1+; SOC available
TM00103 Breast Invasive ductal carcinoma View Data
TM00129 Breast Invasive ductal carcinoma PR-, ER-, HER2 (ERBB2)+
TM00284 Breast Adenocarcinoma View Data
TM00999 Breast Invasive ductal carcinoma View Data

 

Lung tumor models

Our extensive collection of early passage lung tumor models features various combinations of variants including ALK,KRAS, TP53 and EGFR.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00046 Lung Adenocarcinoma SOC availableView data
TM00186 Lung NSCLC: Adenocarcinoma SOC available; View data
TM00192 Lung Adenocarcinoma AURKA F31I; KDR Q472H; Amplification of AURKA,CDK4/6 & EGFR
TM00193 Lung NSCLC: Adenocarcinoma View Data
TM00199 Lung NSCLC: Adenocarcinoma View data
TM00202 Lung NSCLC: Adenocarcinoma View data
TM00203 Lung NSCLC: Adenocarcinoma KRAS G12C; PTEN del
TM00204 Lung NSCLC: Adenocarcinoma View data
TM00206 Lung NSCLC: Adenocarcinoma ELM4; ALKE; View data
TM00208 Lung NSCLC: Squamous cell carcinoma AURKA F31; KDR Q472H; RET G691S; Amplification of CCNE1 & EGFR
TM00214 Lung NSCLC: Adenocarcinoma View Data
TM00219 Lung NSCLC: Adenocarcinoma CTNNB1, EGFR exon 19 del, T790M, KDR, TP53
TM00226 Lung  Adenocarcinoma View data
TM00233 Lung  Adenocarcinoma View data
TM00256 Lung Squamous cell carcinoma View data
TM00302 Lung NSCLC View data
TM00355 Lung NSCLC: Squamous cell carcinoma SOC available; View data
TM00784 Lung NSCLC SOC available; View data

 

Bladder tumor models

Our live bladder tumor models feature an early passage urothelial carcinoma with available gene expression, gene CNV and drug response data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00015 Bladder Urothelial carcinoma SOC available; View data
TM00024 Bladder Urothelial carcinoma SOC available; View data
TM00025 Bladder Urothelial carcinoma View data

 

Brain tumor models

We are featuring a gliobastoma tumor model with available variant summary, gene expression, CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00058 Brain Gliobastoma/edematous glioma View data
TM01087 Kidney Neuroblastoma SOC available; View data

 

Colon tumor models

Our featured live colon tumor PDX model is an early passage colon adenocarcinoma with gene expression, gene CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00165 Colon Anal adenocarcinoma HER2+; View data

 

Sarcoma tumor models

Our featured live spindle cell sarcoma tumor PDX model is an early passage model with gene expression, gene CNV,  and tumor growth data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00381 Soft Tissue Spindle cell sarcoma View data

 

Ovarian tumor models

Our featured live ovarian tumor PDX models is an early passage carcinoma with gene expression, gene CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00327 Ovary Carcinosarcoma SOC available; View data
TM00334 Ovary Carcinosarcoma View data
TM00335 Ovary N/A View data

We also offer a variety of tumors available for engraftment for breast cancer, lung cancer, Bladder cancer, pancreatic cancer, acute myeloid leukemia, ovarian cancer and many others found in the mouse tumor database.

Last updated July, 21, 2015.