PDX LiveTM tumors

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We have partnered with more than 20 cancer clinics to provide access to a wider range of patient-derived xenograft (PDX) cancer models at earlier passage numbers than any other PDX collection available today.

Executing patient-derived xenograft studies is time-consuming, with pre-study engraftment and growth of tumors representing a significant time investment. To streamline PDX cancer study execution, we are offering a collection of PDX LiveTM tumor engrafted NSG mice.

Our collection of readily available, off-the-shelf, tumor engrafted cohorts of PDX mice are developed and maintained by our experienced scientific staff and tumor-bearing mice are ready to quickly enroll on study.

Get your data up to 80% faster

Bringing tumors out of the freezer or passaging tumors between donor and on-study mice can delay PDX drug efficacy studies 6-12 weeks or more. Our inventoried PDX LiveTM tumors significantly shorten this time period by having tumor-engrafted live mice on the shelf and ready to enroll on study as soon as you are ready.

For most of our PDX tumors, gene expression data and genomic data (Affymetrix Human Gene 1.0 ST Exon Array), Genome-Wide Human SNP Array 6.0 from Affymetrix, including CNV data), standard of care data and pathology images are available through the Mouse Tumor Biology Database.

Breast tumor models

We are featuring an off-the-shelf triple-negative breast tumor model from our library of nine early passage triple-negative tumors and an invasive ductal carcinoma with available gene expression, gene CNV and drug response data. The following models are currently growing in mice for quick availability.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00089 Breast Ductal carcinoma Triple-negative (ER-, PR-, HER2-)
TM00090 Breast Invasive ductal carcinoma View Data
TM00091 Breast Invasive ductal carcinoma View Data
TM00096 Breast N/A Activating mutations:AURKA, NRAS, TP53
TM00099 Breast Invasive ductal carcinoma Inactivating mutations:ATM, TP53; Activating mutations: KDR (VEGFR2), TP53
TM00103 Breast Ductal carcinoma View Data
TM00129 Breast Invasive ductal carcinoma View Data
TM00999 Breast Invasive ductal carcinoma View Data

 

Lung tumor models

Our extensive collection of early passage lung tumor models features various combinations of variants including ALK,KRAS, TP53 and EGFR.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00185 Lung Squamous cell carcinoma View Data
TM00193 Lung NSCLC: Adenocarcinoma EGFR exon 19 del; View Data
TM00196 Lung Adenocarcinoma View Data
TM00200 Lung SCLC View Data
TM00204 Lung NSCLC: Adenocarcinoma EGFR exon 19 del; T790M; View Data
TM00206 Lung NSCLC: Adenocarcinoma Activating mutations: ALK, AURKA, ELM4 & FGFR4  
TM00208 Lung NSCLC: Squamous cell carcinoma View Data
TM00213 Lung NSCLC: Adenocarcinoma KRAS G12C
TM00226 Lung NSCLC: Adenocarcinoma KRAS G13R; View Data
TM00233 Lung NSCLC View Data
TM00302 Lung NSCLC: Metastatic adenocarcinoma KRAS G12D; ALK; View Data
TM00355 Lung Squamous cell carcinoma View Data

 

Lymphomas and hematological tumor models

Our live tumor models feature AML FLT3-ITD PDX models with tumor growth rate data, and an AML IDH1 PDX model.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00346 Bone marrow Acute myeloid leukemia FLT3-ITD; NPM1
TM00347 Bone marrow Acute myeloid leukemia FLT3-ITD
TM01505 Bone marrow Acute myeloid leukemia IDH1-R132H; NPM1

 

Bladder tumor models

Our live bladder tumor models feature early passage urothelial carcinomas with available gene expression, gene CNV and drug response data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00015 Bladder Urothelial carcinoma Inactivating mutation:TP53; Activating mutations: PIK3CA, TP53
TM00020 Bladder Urothelial carcinoma View Data
TM00024 Bladder Urothelial carcinoma View Data

 

Brain tumor models

We are featuring a gliobastoma tumor model with available variant summary, gene expression, CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00058 Brain Gliobastoma View Data

 

Ovarian tumor models

Our live ovarian tumor models feature an early passage serous carcinoma with available gene expression, gene CNV and drug response data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00327 Ovarian Serous carcinoma View Data
TM00329 Ovarian N/A View Data
TM00330 Ovarian N/A View Data

 

Colon tumor models

Our featured live colon tumor PDX models is an early passage colon adenocarcinoma with gene expression, gene CNV, histology and tumor growth data.

Model ID Primary site Diagnosis Tumor Markers & Additional Details
TM00164 Colon Adenocarcinoma View Data

We also offer a variety of tumors available for engraftment for breast cancer, lung cancer, Bladder cancer, pancreatic cancer, acute myeloid leukemia, ovarian cancer and many others found in the mouse tumor database.