JAX compound evaluation: neuromuscular and neurodegenerative disorders
JAX compound evaluation services combine proven models of Parkinson's, ALS, and Duchenne's with high-throughput, cost-effective and non-invasive test platforms
Duchenne's muscular dystrophy (DMD)
- Compound testing in a spontaneous model of DMD
- Model: C57BL/10ScSn-Dmdmdx/J
- Readouts:
- Grip strength measurement
- Locomotor testing
- Rotarod
- Forced exercise and exhaustion
- Histopathology
- Sample study: Mouse Model for Duchenne's Muscular Dystrophy (.pdf)
Amyotrophic Lateral Sclerosis (ALS)
- Compound efficacy testing in spontaneous models of ALS
- Models:
- B6SJL-Tg(SOD1*G93A)1Gur/J
- B6.Cg-Tg(SOD1*G93A)1Gur/J
- Readouts:
- Body weight
- Grip strength measurement
- Locomotor testing
- Rotarod
- Histopathology
Parkinson's disease (PD)
- Compound efficacy testing in the MPTP induced model of PD (both chronic and acute models)
- Model: C57BL/6J administered with MPTP (with probenecid for the chronic model)
- Readouts:
- Body weight
- Rotarod
- Grip strength reading
- Locomotor testing
- TH staining
- Histopathology
