In Vivo services for type 2, non-insulin dependent diabetes mellitus
Experimental methods
- Food and water intake
- Body weight
- Body composition
- Body temperature
- Metabolism (indirect calorimetry)
- Activity
- Blood pressure (non-invasive)
- Tissue harvest including collection and weighing of fat pads
- Sample collection - blood, urine, feces
- Blood and urine glucose levels
- Fed and fasted
- Glucose homeostasis
- Oral glucose tolerance test (OGTT)
- Intraperitoneal glucose tolerance test (IPGTT)
- Insulin tolerance test
Selected disease models
|
Comparison of Common Diabetes and Obesity Models | ||||||
|
Human |
NONcNZO10/LtJ |
KK.Cg-Ay/J |
BKS.Cg-m +/+ Leprdb/J |
B6.V-Lepob/J |
||
| Genetics/Degree of Obesity | Polygenic/ Moderate |
Polygenic/ Moderate |
Monogenic/ Moderate |
Monogenic/ Severe |
Monogenic/ Severe |
Polygenic/ Moderate |
| Genetics/Degree of Diabetes (Hyperglycemia) | Polygenic/ Moderate1 |
Polygenic/ Severe1 |
Polygenic/ Severe1 |
Polygenic/ Severe2 |
Polygenic/ Severe1,3 |
Polygenic/ Moderate1 |
| Insulin Resistance | Moderate-Severe | Moderate | Moderate | Severe | Severe | Moderate |
| Islet Atrophy | Variable | Yes | No | Yes | No | No |
| Hypercorticism | No | No | ND* | Yes | Yes | No |
| 1 gradual onset 2 early, rapid onset 3 spontaneous remission of peripubertal hyperglycemia * not determined | ||||||
Supporting services
- Histopathology - UC Davis Comparative Pathology Lab (CPL)
- Blood chemistry including glucose - UC Davis CPL
- Serum insulin - Linco Research
- Leptin, adipokines - Linco Research
- Hemoglobin A1c (HA1c) - UC Davis CPL
Sample study
Download a sample diabetes study design (pdf)
Standard protocol
Print-Friendly Standard Protocol for Type II Diabetes (pdf)
Scientific advisor
Our Study Directors are supported by Jackson Laboratory scientist Ed Leiter, Ph.D.
Print-Friendly In Vivo Services brochure (pdf)
Print-Friendly Efficacy Testing Services for Diabetes & Obesity fact sheet (pdf)
Still have questions?
- Get started using our JAX® Services Request Form
- Ask JAX® Services a question via email.
- Call JAX® Services at 800-422-6423 or 1-207-288-6294.
- Contact your Regional Representative.
