In Vivo services for type 1 diabetes and complications

Experimental methods

  • Dosing by all commonly used routes including:
    per os (p.o., gavage) intramuscular (i.m.) intrarectal (i.r.)
    intravenous (i.v.) subcutaneous (s.c.) food, water
    intraperitoneal (i.p.) intradermal (i.d.) osmotic pump
  • Tissue harvest
  • Biospecimen collection
  • Food and water intake
  • Blood and urine glucose
  • Wound induction

 
Selected disease models

Disease Area

Mouse Model

Insulin dependent diabetes
mellitus (IDDM)		 NOD (autoimmune)
Ins2 Akita (mutation; emerging model for complications)
Alloxan, Streptozotocin toxicity
Complications - wound healing db/db

To search the full collection of JAX® Mice, please visit the JAX® Mice database

Supporting services

  • Histopathology - UC Davis Comparative Pathology Lab (CPL)
  • Blood differential - UC Davis Comparative Pathology Lab
  • Cytokine analysis - Linco Research
  • Immunophenotyping - Gene Logic, SRI
  • Hemoglobin A1c (HA1c) - UC Davis CPL

Sample data

Download protocols and data from a wound healing pilot study (pdf)

Scientific advisors

Our Study Directors are supported by Jackson Laboratory scientists Ed Leiter, Ph.D., David Serreze, Ph.D. and John Sundberg, DVM, Ph.D.

Print-Friendly In Vivo Services brochure (pdf)

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